Job Description
Job Description The Precision Genetics group within the Data and Genome Sciences Department is seeking a-Senior Scientist-to join our-Computational Precision Immunology-team in Cambridge, MA. We are looking for a skilled data scientist with extensive experience in companion diagnosis (CDx) development based on multi-modal and multi-scale data analyses.
Key Responsibilities: - Biomarker Identification and Patient Stratification : Integrate multi-modal omics datasets to develop biomarkers for the patient stratification
- Clinical Data Analysis : Analyze the multi-omics data from internal randomized clinical trials to develop the CDx of immunology clinical trials
- Real World Data Analysis : Integrate Real World Data with machine learning methods for the CDx validation
- Collaborative Research : Partner closely with Clinical Research scientists to develop tailored strategies for the CDx development
- Emerging Methods : Stay at the forefront of novel methodologies in computational immunology for the precision medicine
- Data Set Identification : Proactively identify datasets of autoimmune diseases from public, internal, and proprietary sources through collaborative efforts
- Project Management : Manage complex projects, proactively identifying challenges and forecasting timelines for key deliverables to meet pipeline objectives
- Effective Communication : Present findings to project teams, internal stakeholders, and the broader scientific community through internal documentation, presentations, and publications in leading journals
Qualifications: Education: - Ph.D. in Computational Biology or a related field with relevant research experience listed below
Required Experience and Skills: - Proven track record of three (3) or more years in multi-omics-based patient stratification, real world data analysis and CDx development
- Strong conceptual understanding of generative, discriminative, and contrastive machine learning methods for the feature optimization
- Extensive hands-on experience with Real World Data extraction, cleaning and analysis
- Fundamental knowledge of multi-omics data analysis and integration (e.g. RNASeq, single-cell RNASeq, OLINK)
- Proficiency in coding using R and Python, with the ability to establish best practices for reproducible data analyses
- A collaborative and self-motivated individual with a strong work ethic, ability to work in a dynamic environment and able to manage multiple objectives in parallel and adapt to changing priorities
- Excellent written and verbal communication skills.
Preferred Experience and Skills: - Good understanding of auto-immune disease biology
- Experience in statistical and population genetics principles
#EligibleforERP-
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U.S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".
The salary range for this role is
$128,800.00 - $202,700.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits.- Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at .
You can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: -We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: -We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully- Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. -No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.-
Employee Status: Regular
Relocation: Domestic/International
VISA Sponsorship: Yes
Travel Requirements: 10%
Flexible Work Arrangements: Not Applicable
Shift: 1st - Day
Valid Driving License: No
Hazardous Material(s): No
Required Skills: Bioinformatics, Companion Diagnostics (CDx), Computational Biology, Data Analysis, Data Science, Machine Learning, Omics, Patient Stratification, RNA Sequencing
-Preferred Skills: Job Posting End Date: 06/27/2025
*A job posting is effective until 11:59:59PM on the day BEFORE -the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Requisition ID: R352376
Job Tags
Holiday work, Full time, For contractors, Local area, Remote job, Relocation, Visa sponsorship, Flexible hours, Shift work, 3 days per week,